Bosco Lab

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Members

Daryl A. Bosco, PhD (Principal Investigator)
Associate Professor

Daryl Bosco received her Ph.D. (bio-organic chemistry) in 2003 from Brandeis University, where she used NMR spectroscopy to study enzyme dynamics. From 2003-2005, Dr. Bosco was a post-doctoral fellow in the lab of Jeffery W. Kelly at the Scripps Research Institute, where she studied the effect of oxidative cholesterol metabolites on the misfolding of alpha-synuclein, a Parkinson’s disease-associated protein. Prior to joining the faculty at UMMS in October of 2008, Dr. Bosco was an Instructor of Neurology at Harvard Medical School and worked on various aspects of ALS in the Cecile B. Day lab directed by Dr. Robert H. Brown, Jr. at the Massachusetts General Hospital.

Heather Yonutas, PhD 
Post-Doctoral Fellow


Heather Yonutas received her Ph.D. in 2016 from the University of Kentucky where she investigated the role of mitoNEET in pioglitazone mediated neuroprotection following Traumatic Brain Injury. Upon the completion of her Ph.D., she joined the laboratory of Dr. Daryl Bosco to pursue a research career studying ALS. Although she is new to the lab, she is very familiar with the ALS after watching two of her loved ones wither away under the strain of this horrible disease. This experience, although tragic, gave her a unique passion which drives her as she investigates the stress response in ALS-relevant mutant FUS models.

Eric Schmidt
MD/PhD Candidate

 

Eric graduated from the University of Kansas with a BS in biology and briefly studied Charcot-Marie-Tooth disease as a research assistant at OHSU before entering the MD/PhD program at the University of Massachusetts in 2012.  He joined the Bosco lab in fall 2014 and is pursuing projects related to ALS-linked PFNI stability and interactions.

Yen-Chen (Nora) Lin
PhD Candidate

I graduated from National Yang-Ming University from Taiwan in 2013 and headed straight into the PhD program at UMMS in 2014, joining the Bosco lab in 2015. I am enthusiastic about uncovering the molecular mechanisms underlying neurodegenerative diseases. In my time outside of lab, I love to stay at home, doing nothing. 

Meenakshi Sundaram Kumar (Sundar)
PhD Candidate

I obtained my bachelor’s and master’s degree in biology from the Indian Institute of Science in 2016. I am investigating misfolding of SOD1.

Salome Funes

PhD Candidate

Salome graduated from the Universidad de las Fuerzas Armadas - ESPE (Ecuador) with a BS in Biotechnology and shortly studied infectious diseases as a research assistant at INSPI-IEE before entering the PhD program at the University of Massachusetts in 2016.  She joined the Bosco lab in 2017 and is currently pursuing projects related to the effect of ALS mutations on  PFN1 function.

Crystal Burgess
 PGSP Trainee

Crystal earned a BS in Neuroscience from Agnes Scott College in 2018. Prior to enrolling in the Pathway to Graduate Study Program (PGSP), she worked as an intern at the Alzheimer Disease Research Center (ADRC) in Atlanta, GA. Her research examined how certain blood pressure medications penetrate the brain and effect Alzheimer's Disease biomarkers in African Americans with a parental history of Alzheimer's Disease. She also gained research experience as an undergraduate research assistant at Agnes Scott College where she investigated the role of dysbindin, a subunit of the BLOC-1 complex, in the neuronal morphology of patients with schizophrenia. She joined the Bosco Lab in 2018 and is currently focusing on studying stress granule formation in-vivo. 

Former Bosco Lab Members

Graduate Students
  • Dr. Reddy Ranjith Kumar Sama - Currently working as Sr. Clinical Trial Manager at Alnylam Pharmaceuticals, Cambridge, MA (more information)
  • Dr. Catherine (Ward) Douthwright - obtained her PhD in 2014.   Currently involved in ALS clinical trails at UMMS as a Clinical Research                          Coordinator and Certified Clinical Research Professional (CCRP).          
  • Dr. Melissa Rotunno - obtained her PhD in 2015. Currently working as a post-doctoral fellow in Translational Neuroscience at Sanofi in                          Framingham, MA.
  • Laura Kaushansky - obtained her master's degree in 2015. Currently a Quality Control Manager at Sunovion Pharmaceuticals, MA.
  • Dr. Sivakumar Boopathy  - obtained his PhD in 2017. Currently working as a post-doctoral fellow at Massachusetts General Hospital,                            Department of Molecular Biology,  MA.
  • Dr. Maeve Tischbein- obtained her PhD in 2018.  Currently working as a Postdoctoral Research Fellow at Wave Life Sciences USA, Inc.

Post-Doctoral Fellows
  • Dr. Kristin Boggio - Former post-doctoral fellow, currently a Senior Scientist in Protein Mass Spectrometry at Pfizer, Inc.
  • Dr. Jeanne McKeon -  Former Milton Safenowitz Postdoctoral fellow in the Bosco lab from March 2015 through September 2018.

Staff
  • Katherine Gall - Former laboratory technician, currently employed as a Research Associate at Homology Medicines, Inc., MA.
  • Nathan Lemay - Former laboratory technician, currently employed as an EMT.
  • Desiree M. Baron - Former Research Associate, currently employed as Research Associate II at UMMS.

Summer/Undergraduate Students
  • Frank Trujillo -  Former summer student researcher, currently attending Florida International University
  • Jesus Frias - Former summer student researcher, currently attending University at Albany - SUNY, NY.
  • Victoria Botelho -   Former undergraduate researcher, currently attending nursing school. 
  • Kiera Sapp -  Former summer student, currently a graduate student at MIT, MA.